By binding to the adaptor protein SKP1 and serving as substrate receptors for the SKP1 Cullin, F-box E3 ubiquitin ligase complex, F-box proteins regulate critical cellular processes including cell cycle progression and membrane trafficking.While F-box proteins are conserved throughout eukaryotes and are well studied in yeast, plants, and animals, s
Epithelial ovarian carcinoma (EOC) is the most lethal gynecological malignancy.Herein, we sought to determine the efficacy of phosphoinositide 3-kinase (PI3K)/Akt inhibition using three AZD compounds in a NOD-SCID xenograft mouse model and Akt regulation in a panel of eight ovarian cancer cell lines.Elevated Akt phosphorylation on Ser473 but not on
The study of substances of botanical origin is fundamental for the development of new effective alternatives for the control of Aedes (Stegomyia) aegypti (Culicidae), a vector of arboviruses in humans.In this study, the potential of two new dillapiole derivatives, propyl ether dillapiole and piperidyl dillapiole, was tested to determine their abili
Given the high case fatality rate of SARS-CoV-2, for which there Lift Shock is no cure and no vaccine, clinicians are forced to make decisions about how best to manage patients with limited high-quality evidence to guide treatment.Traditional randomized controlled trials provide strong experimental evidence, however, tend to be slow, inflexible, an